Table of Contents
EDITORIAL
The forgotten clockwork of the brain: Untangling accelerated aging in substance use disorders 1
Julio Licinio
INNOVATORS & IDEAS: RISING STAR
Jeremie Poschmann: Data-driven discovery in human diseases through multi-omics profiling of the circulating immune system 3
Jeremie Poschmann
INNOVATORS & IDEAS: RESEARCH LEADERS
Melissa Perreault: Thinking big towards a “complexity science” approach in neuroscience – systems, environment, and whole organism research 6
Melissa Perreault
Anthony A. Grace: Elucidating the circuitries that underlie schizophrenia and depression may reveal the impact of stress during development and identify novel treatment targets 10
Anthony A. Grace
Consuelo Walss-Bass: Why does my sister have schizophrenia and I do not? Understanding how a person's unique genetic makeup interacts with their environment to shape behavior is one of the final frontiers in medicine 13
Consuelo Walss-Bass
VIEWPOINT
Recent findings and future directions for the intersection of genetic and environmental contributions to schizophrenia 17
Natassia Robinson and Sarah E. Bergen
PERSPECTIVE
Indigenous data protection in wastewater surveillance: balancing public health monitoring with privacy rights 22
Melissa L. Perreault and Lawrence D. Goodridge
THOUGHT LEADERS INVITED REVIEW
Translating stress systems: corticotropin releasing factor, its receptors, and the dopamine system in nonhuman primate models 28
Julie L. Fudge, Emily A. Kelly and Iman Mahoui
RESEARCH ARTICLE
Deciphering the molecular basis of accelerated biological aging in substance use disorder: Integrative transcriptomic analysis 44
Bruno Kluwe-Schiavon, Laura Stertz … Consuelo Walss-Bass
Early infant white matter tract microstructure predictors of subsequent change in emotionality and emotional regulation 53
Yicheng Zhang, Layla Banihashemi … Mary L. Phillips
Cover Art
Insets with TH mRNA+ neurons in red, either single labeled, or co-labeled with VGluT2 (blue) and/or GAD1 (green) mRNA. Simple arrow = single labeled TH+ neurons, arrowhead = TH/VGluT2+ neuron, double arrowhead = triple labeled TH/VGluT2/GAD1 neurons (not all cells are labeled for simplicity). This cover image corresponds to Figure 6C in the paper “Translating stress systems: corticotropin releasing factor (CRF), its receptors, and the dopamine system in nonhuman primate models” by Julie L. Fudge et al. on pages 28–43 in this issue.
Image credit: Julie L. Fudge.
The final cover is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This cover may be reproduced without permission under the terms of this license, provided appropriate credit is given to the authors and to Genomic Press and the content is not modified or used for commercial purposes.
Copyright © 2025 Genomic Press. All rights reserved.
This issue is now available at https://url.genomicpress.com/2p8njsrw.
