Cover Image: A laboratory mouse reaches toward an illuminated lightbulb in a vibrant, psychedelic-inspired setting, symbolizing the enhancement of cognitive flexibility following psychedelic treatment. The architectural columns frame a scene where traditional neuroscience meets the transformative potential of psychedelic research, while rainbow-hued patterns evoke the neural plasticity changes induced by serotonin 2A receptor activation. This artistic representation captures the key finding by Brouns et al. that a single dose of the psychedelic 25CN-NBOH produces sustained improvements in reversal learning and cognitive adaptability lasting weeks after administration, as demonstrated through automated behavioral paradigms (pages [29–35]). The imagery reflects the emerging understanding of how psychedelics may restore cognitive flexibility impaired in depression, PTSD, and neurodegenerative conditions through promotion of structural remodeling in the prefrontal cortex.

Provided by Omar J. Ahmed, CC BY 4.0

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