Table of Contents
EDITORIAL
Counting the uncountable: The critical quest to quantify psychedelic medicine's reach 1
Julio Licinio
INNOVATORS & IDEAS: RISING STAR
Alaina M. Jaster: Bridging the gap across preclinical and clinical disciplines in the psychedelic sciences 3
Alaina M. Jaster
Fayzan Rab: What are the economic and public health implications of psychedelic therapies? 6
Fayzan Rab
INNOVATORS & IDEAS: RESEARCH LEADER
Charles L. Raison: Elucidating the role of conscious experience in the therapeutic effects of psychedelics as a means to optimize clinical outcomes 10
Charles L. Raison
COMMENTARY
Psilocybin-assisted psychotherapy: Advancements, challenges, and future directions for treating resistant depression 13
Rodolfo Myronn de Melo Rodrigues
THOUGHT LEADERS INVITED REVIEW
Effects of ayahuasca on fear and anxiety: cross-talk between 5HT1A and 5HT2A receptors 15
Lorena Terene Lopes Guerra, Rafael Guimarães dos Santos, and Jaime Eduardo Cecilio Hallak
RESEARCH REPORT
An estimate of the number of people with clinical depression eligible for psilocybin-assisted therapy in the United States 26
Syed F. Rab, Charles L. Raison, and Elliot Marseille
What motivates spiritual health practitioners in psychedelic-assisted therapy? A qualitative study and implications for facilitator training practices 31
Ishan Pasricha, Roman Palitsky … Deanna M. Kaplan
Cover Art
An urban twilight scene depicting the intersection of modern society and psychedelic medicine's emergence into mainstream healthcare. The glowing digital display showing “5.1M” symbolizes the mid-range estimate of 5.1 million patients with major depressive disorder who could potentially benefit from psilocybin-assisted therapy according to research findings. The cityscape at dusk—with its gradient purple-orange sky and illuminated buildings—represents the transitional period in which psychedelic treatments are moving from experimental research into regulated medical practice. The taxi in the foreground suggests the journey toward new therapeutic destinations, while the various digital screens and urban elements reflect the complex healthcare system through which novel treatments must navigate. This visualization connects to the paper “An estimate of the number of people with clinical depression eligible for psilocybin-assisted therapy in the United States” by Syed F. Rab et al. on pages 26-30 in this issue, which analyzes potential patient populations for this emerging treatment modality.
Cover design generated through extensive and iterative human-AI collaboration using Claude by Anthropic and Grok (created by xAI) AI assistants. The final cover is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This cover may be reproduced without permission under the terms of this license, provided appropriate credit is given to Genomic Press and the content is not modified or used for commercial purposes.
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