Table of Contents
EDITORIAL
From vulnerability to protection: The dual nature of ADNP variants 1
Julio Licinio
INNOVATORS & IDEAS: RISING STAR
Pierre-Eric Lutz: The role of epigenomic plasticity in the emergence and protracted course of psychiatric disorders 4
Pierre-Eric Lutz
INNOVATORS & IDEAS: RESEARCH LEADERS
Kerry J. Ressler: Exploring the translation of amygdala function at the cellular and genomic levels to understand stress, fear, and trauma disorders, such as post-traumatic stress disorder (PTSD) 7
Kerry J. Ressler
Cathy Barr: Genetics and neurobiology of childhood psychiatric and cognitive disorders 11
Cathy Barr
Yogesh Dwivedi: Pre-clinical and translational research focusing on gene regulation through epigenetic and epitranscriptomic mechanisms and their implications in mood disorders and suicidal behavior 14
Yogesh Dwivedi
VIEWPOINT
The association between trace amine-associated receptor 1 (TAAR1) genetic mutations and neuropsychiatric disorders 17
Britto Shajan, Tarun Bastiampillai, and Pramod C. Nair
THOUGHT LEADERS INVITED REVIEW
Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders 21
Bhaskar Roy, Anuj Kumar Verma … Yogesh Dwivedi
Roles of alternative polyadenylation in psychiatric disorder risk 34
Michelle Paff, Steven F. Grieco … Xiangmin Xu
RESEARCH ARTICLE
Sex differences in alcohol and tobacco use disorders among individuals with panic disorder: a cross-sectional analysis from the genomic psychiatry cohort 42
Michael J. Chung, Penelope Georgakopoulos … Michele T. Pato
RESEARCH REPORT
Protective inherited mutations in activity-dependent neuroprotective protein (ADNP): the good, the bad, and the ugly 49
Illana Gozes, Shula Shazman … Joseph Levine
Cover Art
Cover Art: An artistic visualization capturing the molecular mechanisms of activity-dependent neuroprotective protein (ADNP) function in brain development. A central DNA double helix, rendered in luminescent blue, represents the ADNP gene, while the spherical structures with radiating points illustrate the 14-3-3 protein binding sites critical for ADNP protein’s nuclear-cytoplasmic shuttling. The crystalline texture of these molecular structures highlights their complex interactions, while the soft orange bokeh effects in the background suggest the broader neuronal environment where these interactions occur. This visualization reflects the paper’s findings about protective inherited mutations in ADNP and their impact on neurodevelopment. For more information, please refer to “Protective inherited mutations in activity-dependent neuroprotective protein (ADNP): the good, the bad, and the ugly” by Illana Gozes et al. on pages 49-55 in this issue.
Cover design created through extensive and iterative human-AI collaboration using Claude and Grok AI assistants. The final cover is licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This cover may be reproduced without permission under the terms of this license, provided appropriate credit is given to Genomic Press, and the content is not modified or used for commercial purposes.
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